ABSTRACT

Sustained release (SR) tablets were developed for prolonged release of Ciprofloxacin incorporating Hydroxypropyl methylcellulose (HPMCE5LV) as a controlled release polymer. The current research work was to formulate SR tablets of Ciprofloxacin. Based on various concentrations of HPMC four different batches of SR tablets of Ciprofloxacin are developed through wet granulation process. Pre-compression plus post-compression parameters of SR tablets are measured. Based on the highest drug release F4 was found to be the best among all batches. The % Cumulative drug release (CDR) for F4 was 98.484 % of Ciprofloxacin at the end of the14 hours. The drug release was prolonged due to more amount of HPMCE5LV in F4.It is obtained from the results for all formulations that the release rate of active pharmaceutical ingredients can be controlled through the polymer of the core as well as following zero order kinetics. The Accelerated stability studies (ASS) confirmed that there were insignificant alternates in evaluated parameters at the end of 3 months of F4 batch. Hence the current technology for designing tablets can produce more advantages than conventional tablets. Keywords: Sustained Release, Controlled Release, Ciprofloxacin, Wet granulation
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8553.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.8553