ABSTRACT

Background: Ayurveda, the oldest medical system, focused on preventing diseases and maintaining a healthy body. Nowadays cancer is a global concern. In Ayurveda, cancer treatment can be correlated with arbuda, apachi, granthi roga, etc. A prospective study is being conducted to evaluate the effect of Pathyadi kvatha on Hepatocellular carcinoma classically which is mentioned for yakrita (liver) and pleeha (spleen) roga (disease). Material and methods: The Pathyadi kvatha formulation extract was prepared in aqueous and Hydro-alcoholic media. Classically, the ratio of ingredients for kvatha is not mentioned in shloka (verse). So, the general ratio mentioned in Sharangdhara Samhita was followed. The ratio of ingredients that canbe used for kvatha preparation was followed for extract preparation and tested for antiproliferative activity by MTT Assay. Results: Pathyadi Kvatha's water-soluble extract showed to be more effective than the Hydro- alcoholic extract. The Hydro-alcoholic extract of the standard drug Cisplatin was substantially less efficient in each interval than the aqueous extract of Cisplatin. When data of water-soluble extract of Pathyadi kvatha was compared with water soluble extract of Cisplatin it was found that Cisplatin was better than Pathyadi kvatha. Conclusion: In the current study, extracts of medications specified in the Pathyadi Kvatha formulation were employed in the same ratio as the kvatha preparation. Individually, extracts of these drugs have shown anti-cancerous activity in various research models. Further, in vivo and clinical research is needed to understand the formulation's effects completely. Keywords: Pathyadi kvatha, Cancer, Hepatocellular carcinoma, Ayurveda
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8545.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.8545