ABSTRACT

Developing an eco- friendly process for synthesis of nanoparticles is a noteworthy step in the field of green nanotechnology. It involves the tailoring of materials at the atomic level to achieve unique properties, which can be rightfully operated for the required therapeutic applications for various diseases. In the present work, bimetallic silver-iron bimetallic nanoparticles (BMNPs) are synthesized from silver nitrate (AgNO3) and ferrous sulphate (FeSO4) precursor solutions using aqueous leaf extract of medicinal plant Aerva lanata. The phyto molecules of the leaf extract are functioned as bio-reducing, stabilizing and capping agents. The synthesized BMNPs are characterized using UV-Vis spectroscopy, FTIR, SEM, EDX, XRD and TEM analytical techniques. The cytotoxic response is assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (MTT) assay. These biogenic Ag-Fe BMNPs is found to be significantly toxic to MCF-7 cells (human breast cancer cells) via induction of apoptosis. Keywords: Bimetallic nanoparticles (BMNPs), Aerva lanata (AL), Phyto molecules, cytotoxicity
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8543.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.8543