ABSTRACT

In the case of benzoic acid derivatives particularly, monoprotodecarboxylation is a chemical reaction in which a single carboxyl group from a molecule is removed. A new molecule which is called a carbanion, which has one less carbon atom and a positive charge, is created as a result of this reaction. For the effective removal of a single carboxyl group from benzoic acid derivatives, copper (Cu) catalysts in monoprotodecarboxylation processes have gained popularity. Protodecarboxylation for a variety of benzoic acids (substituted) catalyzed by CuCO3 and Acetic acid in DMSO is explained. The monoprotodecarboxylation is a process which can also done by this methodology for heteroaromatic carboxylic acid and aromatic carboxylic acid. Due to their capacity to form stable complexes with the substrate and promote the transport of electrons, copper catalysts have been discovered to be extremely effective in promoting this reaction. In comparison to conventional techniques that are use strong bases, it has been demonstrated that the use of copper catalysts in monoprotodecarboxylation processes results in the faster reaction rates, higher yields, suitable temperature and more selective product production. The potential of copper catalysts as an effective and affordable substitute for the monoprotodecarboxylation of benzoic acid derivatives is highlighted by this. Keyword: Protodecarboxylation, benzoic acids (substituted), Copper carbonate, Dimethyl sulfoxide (DMSO)
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8526.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.8526