ABSTRACT

Naturally occurring herbal excipients are always interesting and show many advantages during drug formulation. The excipients are acknowledged to play substantial role in the quality of drug products. Binders and disintegrants are the two critical categories of excipients used in the manufacturing of solid dosage forms. The objective of the current work was to examine the utility of peanut husk powder as a disintegrating agent in formulating fast-dissolving tablets containing indomethacin. Total six formulations were developed using different disintegrating agents employing wet granulation method. All the pre-compression measurements, including angle of repose, carr’s compressibility index and hausner’s ratio were determined. Evaluation tests like weight variation, friability, hardness and disintegration test and drug dissolution study were conducted for the formulated tablets. The acquired results were tabulated and analyzed systematically by appropriate methods. The tablets formulated in this study were found to meet the acceptable range of all the quality control tests performed. The formulation prepared with peanut husk powder as disintegrating agent was identified to be the best formulation as it disintegrated and dissolved rapidly. Peanut husk powder developed from natural plant source was found to be a potential superdisintegrant in formulating indomethacin fast dissolving tablets. Keywords: Fast dissolving tablets, Peanut husk powder, Superdisintegrant, Indomethacin, Wetting time, Dissolution studies
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8509.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.8509