ABSTRACT

In this investigation, we tried developing a precise and reliable stability assay method for paracetamol and Zaltoprofen simultaneous measurement in API and pharmaceutical dosage forms using RP-HPLC. To obtain adequate separation, an Agilent TC C18 column was used, and a PDA detector was used for the study. 0.2% Triethylamine: Acetonitrile (50:50 v/v) mixture, flowing at 1 milliliter per minute. Using a diode array detector, the eluent at 243 nm was observed. The retention time of paracetamol is 3.0 while that of Zaltoprofen is 5.2. With a correlation coefficient better than 0.99, the measured signal was demonstrated to be precise, accurate, and linear over the concentration range evaluated. The current method's accuracy was assessed at 80%, 100%, and 120%. Recovery rates for both paracetamol and Zaltoprofen is 100.2% and 98.93%, respectively, the HPL.C. Method for determining the assay of Paracetamol and Zaltoprofen is correct. There was determined to be a precision RSD within range. The RP-HPLC approach may be successfully employed for the simultaneous measurement of Paracetamol and Zaltoprofen in their formulation, as demonstrated by the results from the preceding data. Keywords: RP-HPLC, Zaltoprofen, Paracetamol, PDA detectors
Publication date: 01/11/2024

https://ijbpas.com/pdf/2024/November/MS_IJBPAS_2024_9634.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.11.9634