ABSTRACT

Inflammation contributes as a key factor for retarding the process of dermal wound healing. Trianthema portulacastrum Linn. reported to possess antioxidant, antifungal, anti-inflammatory and antibacterial properties, which could make TP a promising wound healing agent. In the current study Wound healing potential of Chloroform extract of TP using excision and incision wound model was studied. Wistar albino rats were randomly divided into four groups, containing six animals in each group; group I served as control untreated, group II was standard group, treated with Soframycin skin cream, group III treated with Chloroform extract with 100mg/kg, and group IV treated with Chloroform extract with 200mg/kg. All the groups were topically applied their respective treatments, once daily, till the complete healing achieved. Wound healing was assessed by analyzing % wound closure, epithelialization period, tensile strength. 100mg/kg and 200mg/kg extracts significantly accelerated the wound healing process dose- dependently in both wound models, evidenced by the faster rate of wound contraction, epithelialization, high tensile strength compared to the control group. There exists a dose-dependant amelioration of wound healing by re-epithelialization of the wounded skin sample in Chloroform extract of Trianthemaportulacastrum treated groups. These results implicate potential medicinal value of Chloroform extract of Trianthema portulacastrum to heal dermal wounds. Keywords: Trianthema portulacastrum, wound healing activity, Incision model, Excision wound model, chloroform extract
Publication date: 01/11/2024

https://ijbpas.com/pdf/2024/November/MS_IJBPAS_2024_8433.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.11.8433