ABSTRACT

Present abstract employs the use of Multivariate Calibration Technique for the assessment of Meclizine hydrochloride in the marketed pharmaceutical formulation. The multivariate calibration method was developed by utilizing a linear regression equation to analyze the relationship at five distinct concentration levels and recording its absorbance at five different wavelengths close to the drug's maximum absorbance. Over a concentration range of 5–15 g/mL, the technique was shown to be linear with a correlation coefficient value greater than 0.998. Meclizine hydrochloride's ?max was discovered to be 230 nm. According to ICH protocol Q2 (R1), the created approach was determined to be easy, quick, accurate, and exact. By removing the discrepancies the resulting from instrumental or experimental conditions, this statistical approach produces optimal results. Keywords: Meclizine hydrochloride, Antihistamine, Multivariate calibration technique, ICH protocol, Validation, UV Spectrophotometry
Publication date: 01/10/2024

https://ijbpas.com/pdf/2024/October/MS_IJBPAS_2024_8379.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.10.8379