ABSTRACT

In this investigation, the effectiveness of cubosomes filled with fruit extract from Momordica dioica against experimentally induced cardiac fibrosis in rats will be assessed. Male Sprague Dawley rats were given twice-weekly doses of deoxycorticosterone acetate (DOCA), 1% NaCl in drinking water, and uninephrectomy to promote cardiac fibrosis. The experimental rats were split into four groups of eight each, with the groups named Sham Control, Surgical Control, Model Control, and Treatment Control (Formulation dose: 104 mg/kg). After the treatment protocol was followed, anthropometric, hemodynamic, biochemical, ex-vivo Langendorff investigation, and antioxidant parameters were carried out. The histology of the heart stained with Masson's trichrome was also investigated. Momordica dioica fruit extract-loaded cubosomes had cardio-preventive benefits by reducing blood pressure, preserving normal ECG patterns, and improving left ventricular functions, as demonstrated by a substantial reduction in LVEDP. The therapy groups have higher serum creatinine levels and lower levels of urea and blood urea nitrogen. The activity of antioxidant enzymes was also increased. Additionally, cardiac homogenate from animals that had been treated had less collagen I and III. By looking at the animal hearts that had been stained with Masson's, this protective effect was further demonstrated. Keywords: Momordica dioica, Novel Cubosomes formulation, cardiac fibrosis
Publication date: 01/10/2024

https://ijbpas.com/pdf/2024/October/MS_IJBPAS_2024_8267.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.10.8267