ABSTRACT

Simple, precise and accurate UV-Spectrophotometric simultaneous equation method for estimation of Azilsartan medoxomil (AZM) and Chlorthalidone (CTD) were developed and validated as per ICH guidelines. This Method involves solving of simultaneous equations based on measurement of absorbance at two wavelengths 244 nm and 272 nm (?max of AZM and CTD) in methanol: water (80:20v/v). Both the drugs obey the Beer’s law in the concentration ranges 5-25 and 10-50?g/ml for AZM and CTD respectively. % Recovery for both the drugs was in the range of 99.82±0.308 % indicating excellent accuracy. The methods were precise, with a relative standard deviation of less than 2% for both drugs. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus, method can be used for routine monitoring of drugs in industry for the assay of bulk drugs and commercial formulation. Keywords: Azilsartan medoxomil, Chlorthalidone, Spectrophotometric analysis, Simultaneous equation method
Publication date: 01/10/2024

https://ijbpas.com/pdf/2024/October/MS_IJBPAS_2024_7272.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.10.7272