ABSTRACT

Aceclofenac’s poor solubility in water was improved by the use of an inclusion complex with hydroxy-Cyclodextrin. Eggshell powder (ESP) was explored for the new application as pharmaceutical excipients and a rich natural source of calcium. The inclusion complexes were created using drugs to cyclodextrin (CD) ratios, 1:1, 1:2, and 1:3. Comparing the outcomes of all 3 formulations, the 1:2 drug-cyclodextrin combination produced superior outcomes. Matrix tablets were prepared by using Drug-Cyclodextrin inclusion complex and egg shell powder (F1-F4) by the direct compression method. The USP Dissolving Apparatus II was used to examine the In-vitro activity of all formulations in pH 6.8 buffer. Multiple physical evaluation tests were used to evaluate the formulation of the matrix tablets. The hydrophobicity of the modified ESP depends on type of solvent employed in the surface alteration process, which may explain about drug's extended release. After chloroform treatment, the sustained release profile of eggshell powder was higher. Keywords: Aceclofenac, hydroxy-Cyclodextrin, Eggshell powder, Matrixtablets, Sustainedrelease
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8339.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8339