ANTIUROLITHIATIC PHARMACOLOGICAL STUDIES ON PUNICA GRANATUM LINN Authors: Diana K. J.
ABSTRACT
Urolithiasis, often known as kidney stone disease, is a frequent clinical ailment.
According to statistics, 12% of the world's population suffers from urinary stone illness.
Disease frequency is increasing as a result of global warming, lifestyle, and eating habits.
Traditional Botanical Knowledge (TBK) has assisted man in isolating medications for a wide
range of ailments and will continue to be a valuable source for future drug development
research. Punica granatum Linn. is one of the herbal remedies commonly used to treat
urolithiasis. The latest study suggests that kidney stones begin as an aggregation of calcium
phosphate crystals. In this context, rind extract of Punica granatum Linn. were subjected to
screening of their antiurrolithiatic property by studying its potential for growth inhibition of
Calcium Hydrogen Phosphate Dihydrate crystals (CHPD) crystals employing crystallographic
techniques.For this, single diffusion gel growth technique was used. Reduction in growth of
treated crystals was noticed with increasing concentrations of plant extract. The morphology
of CHPD (brushite) crystals was studied by microscopy. Characterization of gel grown CHPD
(control) and rind extract treated crystals by FT-IR, XRD and TGA/DTA analysis revealed
the structural and chemical changes of the treated crystals.
Keywords: Urolithiasis, Punica granatum, Calcium hydrogen phosphate dihydrate, FT-
IR, TGA/DTA and XRD Publication date: 01/09/2024 https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8331.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2024/13.9.8331
