ABSTRACT

Pain is often defined as a single form of the nervous system for abnormal things in the human body. Neuropathic pain (NP) is a kind of pain that is a worry of nerve damage and usually, it is a chronic type. Sodium Channel 1.7 (Nav 1.7) is an forthcoming biological target against neuropathic pain management. Several heterocyclic compounds are reported for potentials against neuropathic pain. 10 different heterocyclic derivatives from thiadiazole class were synthesized,virtually analyzed against Nav 1.7 for inhibition potential and carry out biological activity by Streptozotocine (STZ) induced diabetic pain model. The developed thiadiazole were confirmed via spectral analysis and showed excellent binding ability with Nav 1.7, which can be further sightseen for biological activity. Keywords: Pain, Neuropathic pain, Thiadiazole, Docking, STZ
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8323.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8323