ABSTRACT

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and neuropathological changes, including the accumulation of beta-amyloid plaques and tau tangles in the brain. Preclinical animal models play a crucial role in advancing our understanding of AD pathogenesis and in the development of potential therapeutic interventions. This review explores various preclinical animal models utilized in Alzheimer’s disease research, encompassing Streptozotocin Induced Model, Amyloid-Induced Model, Colchicine-Induced Model, Okadaic acid-induced neuroinflammation, Scopolamine-Induced Model and many others will see in detailed manner. These models will elucidate the disease mechanisms and testing novel therapeutic strategies. Additionally, methodological considerations, limitations, and recent advancements in refining these models for improved fidelity are discussed. A comprehensive understanding of the strengths and limitations of preclinical animal models is imperative for bridging the gap between basic research and clinical translation in the pursuit of effective treatments for Alzheimer’s disease. Keywords: Alzheimer’s disease, preclinical models, animal models, neurodegeneration, beta-amyloid, tau pathology
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8311.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8311