ABSTRACT

Nanofiber (NF) represents one of the newest, promising and advanced technologies in transdermal and oromucosal drug delivery due to its unique advantages. The present study aims to fabrication of electrospunned pentoxifylline loaded biocompatible PVA: PVP based nanofibrous mucoadhesive film for the oral submucous fibrosis. The fabricated NF film mechanical and physicochemical properties were assessed. These nanofibers were then characterised for drug content, FTIR, DSC, SEM), XRD analysis, in-vitro diffusion and ex-vivo permeation studies using franz diffusion cells. The SEM and IR elucidated the thin, uniform, smooth surface of NF without bead formation and interaction between drug and polymers. The PXRD and DSC revealed the molecular dispersion with less crystalline nature of the NF. The diffusion and permeation study resulted initial burst release with gradual diffusion with zero order kinetics. Using the electrospinning approach, PTX-loaded nanofiber film was successfully fabricated and can be explored as biocompatible film for the effective cure of oral Submucous Fibrosis. Keywords: Nanofiber, Electrospinning, Pentoxifylline, Oral Submucous Fibrosis
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8309.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8309