ABSTRACT

Bempedoic acid is a newer one for cardiovascular disease treatment. It generally alters the cholesterol synthesis pathway. This suppression affects fatty acid synthesis, lipogenesis and low- density level cholesterol. Previous trials of bempedoic acid showed fewer side effects as compared to other drugs used for hypercholesteremia. Fixed combinations of atorvastatin and bempedoic acid have sparked a rising interest in studying their probable synergistic effect when combined. During its studies, method development is one of the initial processes that includes optimizing analytical parameters such as chromatographic conditions, its settings, mobile phase selection and composition, and detection wavelength for efficient separation and quantification of both of these drugs in varied biological samples for analysis. This review article includes literature reports from past developments of these drugs, singly or in combination with others. Therefore, the finding reveals the potential to conduct further research and enhancements for treating cardiovascular diseases. Keywords: Analytical method, Atorvastatin, Bempedoic Acid, HPLC, HPTLC, UV
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8302.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8302