ABSTRACT

This study aims to establish an UV-Visible spectroscopic technique to develop an easy, sensible, and reproducible method for Methimazole by applying a multivariate regression equation. Recommended technique depends on the equation of the linear regression performed by taking absorbance at five distinct wavelengths. Methimazole’s maximum absorbance value was obtained at 252 nm. Graph obtained from concentration 35 - 65?g/mL resulted in linear curve and the regression coefficient was obtained as 0.999. %RSD values for Intra-day, as well as inter-day precision, was obtained as 0.3032 and 0.299. The assay value determined was between 99.84% - 100.18% w/w. Keywords: Methimazole, Anti-thyroid agent, Multivariate calibration, UV-Visible spectroscopy, Assay, ICH guidelines
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8297.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.8297