HARNESSING OF STIMULI-RESPONSIVE POLYMERS TO OVERCOME THE CHALLENGES OF DRUG DELIVERY Authors: Cherian MC , SHARMA PK*, DWIVEDI S, GUPTA A AND DARWHEKAR GN
ABSTRACT
Smart polymers that are also known as intelligent polymers or stimuli-responsive polymers
have gained an interest in researchers due to its ability to deliver the drug at an appropriate time
to an appropriate site under specific physiological condition. These polymers produces its
action in response to the stimuli like temperature, pH, light, magnetic field, electric field and
many more. Due to this reason, stimuli-responsive polymers are distinct from other
conventional formulations. Many advantages are associated to smart polymers which have
attracted the attention of the researchers such as ability to release the drug to particular site in
a particular manner, but, due to their slow responsive behavior to certain stimuli and less
clinical data, impedes the growth of smart polymers. Utilization of polymer based nano-
structures (liposomes, niosomes etc.) can contribute in delivering the drug to the target site thus
reducing the chances of toxicity. Therefore, this review article focuses on the types of smart
polymers, advantages and disadvantages, application in the medical field, challenges of drug
delivery through smart polymers and the future prospects of stimuli responsive polymers.
Keywords: Intelligent polymer, stimuli-responsive polymer, smart polymer, nano-structures Publication date: 01/09/2024 https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_8021.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2024/13.9.8021