ABSTRACT

Oral mucosal drug delivery system is widely applicable as novel site for administration of drug for immediate and controlled release action by preventing first pass metabolism. Ginger is a complex substance consisting of more than 60 compounds. Ginger is a popular herb for its culinary and medicinal value. Ginger is antiemetic by multiple mechanisms, ginger ethanolic extraction acted by inhibiting central and peripheral muscarinic and histamine-1 receptors, 5-HT3 receptor antagonist. Buccal patches were prepared with Gingerole with polymers such as Hydroxy Propyl Methyl Cellulose in a respective solvent such as Ethanol with Propylene glycol as the plasticizer and Sorbitol Liquid as sweetening agent. Buccal patches were successfully formulated by solvent casting technique with several concentrations of polymers and those prepared patches were characterized in terms of film thickness, film weight, color, surface texture, folding endurance, surface pH, swelling behavior and percentage of moisture loss. Keyword: Ginger, Antiemetic, Gingerol, Mucoadhesive Buccal Patch
Publication date: 01/09/2024

https://ijbpas.com/pdf/2024/September/MS_IJBPAS_2024_7890.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.9.7890