ABSTRACT

Nitrogenous heterocyclic compounds have recently attracted the interest of medicinal chemists. Benzimidazole scaffolds are surprisingly common in these potential heterocyclic molecules. It has numerous pharmacological properties and so plays a key role in medicinal chemistry and drug discovery. Substitution of the benzimidazole nucleus is an important synthetic method in the drug development process. The importance of benzimidazole derivatives as chemotherapeutic medicines in many clinical circumstances may be linked to their isostructural pharmacophore of naturally occurring active biomolecules. Researchers have generated a large number of benzimidazole derivatives over the last few decades, and a major fraction of these compounds have exhibited tremendous biological efficacy against a variety of diseases, as well as excellent bioavailability, safety and stability features. In this comprehensive study, we have summarized the biological activity of the benzimidazole derivatives reported in recent literature, as well as known structure-activity connections. The broad- spectrum pharmacological activity of compounds with benzimidazole nucleus include common antibacterial properties as well as the capacity to treat the most serious illnesses. A variety of promising therapeutic prospects are undergoing human trials, with some of them being approved for usage in clinical settings. Significant difficulties, such as drug resistance, costly and time-consuming synthetic techniques, a lack of sophisticated software, limited structural knowledge of receptors, and others, can yet be solved to allow for more research. Keywords: Benzimidazole, isostructural pharmacophore, drug resistance, biological activity, anti-bacterial effect
Publication date: 01/08/2024

https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8262.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.8.8262