ABSTRACT

The rise in antimicrobial resistance among pathogenic bacteria species is currently a problem in the clinical setting and treatment of wound infections are increasingly, becoming a challenge. This study assessed, the in vitro antibacterial activity of some commonly used antibiotics in Ebonyi State, against Staphylococcus aureus, Pseudomonas aeruginosa and Proteus mirabilis isolated from patients’ wounds. Hundred and fifty (150) wound samples collected from patients attending Alex-Ekwueme Federal University Teaching Hospital, Abakaliki (AE-FETHA) (N=98) and General Hospital Uburu (GHU) (N=52) were used for the study. Structured questionnaires were used to get demographic information about the patients. Wound samples were collected using sterile swab sticks. The bacteria species were isolated and identified by standard microbiological methods. Antibiotics Susceptibility test was performed by Kirby-Bauer-CLSI modified Disc Agar Diffusion method. Results of socio demographic data from the hospitals showed that the greatest number of the wound patients were between 31-45 years of age for both hospitals. Males have more wounds than females for both hospitals too. Wound samples, obtained from accident victims had the highest frequency for AE-FETHA, andfor GHU, followed by burns, surgical and animal bites. The prevalent rate of the three bacteria species from AE-FETHA wound samples were; Pseudomonas aeruginosa (46.7%), Staphylococcus aureus (46.7%) and Proteus mirabilis (6.6%), and their prevalent rate from GHU wound samples were; Pseudomonas aeruginosa (64.3%), Staphylococcus aureus (28.6%) and Proteus mirabilis (7.1%). Result of the antibiotics susceptibility tests, showed that all (100%) of the bacteria species were susceptibile to imipenem. Some Staphylococcus aureus isolates were susceptible to the other antibiotics while being totally (100%) resistant to ceftriaxone. Pseudomonas aeruginosa showed degrees of susceptibility to the other antibiotics. Proteus mirabilis was found to show 50% susceptibility to meropenem and ofloxacine, while being totally (100%) resistant to the other antibiotics. The antibacterial agent; Imipenem, being hundred percent (100%) active against the tested bacteria species, is therefore, recommended as the antibiotics of choice in treating wound patients infected with the bacteria species in the studied locality. Keywords: Antibacterial agents, Antibiotics, Infection, Patients, Wound
Publication date: 01/08/2024

https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8256.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.8.8256