ABSTRACT

By ratio first-order derivative spectroscopy, a method for simultaneous estimation of Teneligliptin hydrobromide hydrate (TNG) and Pioglitazone hydrochloride (PIO) in bulk medication and their combined dosage form has been devised. This approach is based on dividing the spectra of a mixture by the standard spectra of the analytes, and the spectra were recorded with = 16 nm and a scaling factor of 10. By estimating the first derivative signal at 238.60 nm and 262.85 nm, respectively, the amount of TNG and PIO in the binary combines was determined. In the concentration ranges of 2-12 g/mL for TNG and 1.5-9 g/mL for PIO, the calibration curve was linear. All validation parameters were carried out in accordance with ICH recommendations. The technology was successfully employed for simultaneous drug estimation. Keywords: Teneligliptin hydrobromide hydrate, Pioglitazone hydrochloride, Ratio derivative method, Simultaneous estimation
Publication date: 01/08/2024

https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8250.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.8.8250