Heterocyclic compounds are cyclic ring structures with at least one atom other than carbon,
such as nitrogen, oxygen, or sulfur. Heterocycles can be utilized as starting materials to
manufacture a variety of chemical molecules. A. Vogel of Munich isolated coumarin from
tonka beans for the first time in 1820. Coumarin analogues can be produced using methods
such as the Claisen rearrangement, the Perkin reaction, the Pechmann reaction, the Witting
reaction, and the Knoevnagel condensation. But Pechmann Condensation process is simple,
inexpensive, has a rapid response time, and eliminates the formation of acidic waste streams
caused by traditional methods. Many experts and scientists have reported on this. Resorcinol
and ?-keto ester are condensed with H2SO4 in the Pechmann condensation reaction to produce
coumarin. Coumarin is a natural substance extracted from plants that has a variety of biological
actions. Coumarin, also known as 1,2-benzopyrone, 2H-1-benzopyran-2-one,
phenylpropanoids, cis-o-coumarinic acid lactone, or coumarinic anhydride; tonka bean
camphor, is a broad class of chemicals found in plants, fungi, and bacteria. Coumarin and its
derivatives are physiologically active and highly potent chemicals with antibacterial,
anticancer, anti-HIV, anti-inflammatory, anticoagulant, and antioxidant effects. Coumarins
were formerly believed to be benzoic acid derivatives, but Perkin, Sr.'s methodology
categorized them as oxygenated heterocycles. Schiff bases are the most often utilized flexible
ligands, and they are made via condensation of primary amines with carbonyl compounds. In a wide variety of fields, including agrochemicals, reagents, catalysis, medicine, and the creation
of numerous industrial products, metal complexes of Schiff base ligands are used. Schiff base
complexes are valuable in pharmaceutical applications due to their vast range of biological
activity.
Keywords: Coumarin Synthesis, Co-ordination Chemistry, Metal Complexes, Heterocyclic
compounds, Antimicrobial Activity, Coumarin derivatives
Publication date: 01/08/2024
https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8248.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.8.8248
