ABSTRACT

Microsponges based drug delivery and its manufacturing technology was introduced in pharmaceutical industry in the year 1987.The primary aim was to provide controlled and localized release of active drug ingredient by this technique. Their application to the skin proven to have decrease systemic exposure and reduce local dermal reaction to active drug moiety. Microsponges are polymeric delivery system composed of porous microspheres, typically 10-25 microns in diameter. They are tiny sponge-like spherical particles with a large porous surface. Their porous nature and reduced size decreases the side effects and modify drug release favorably. This delivery system provides extended release with reduced irritation, better tolerance, improved thermal, physical and chemical stability. The main goal of any drug delivery system is to achieve desired concentration of the drug in tissues, that is therapeutically effective and non-toxic over the entire duration of action. Several manufacturing techniques of microsponges based on diffusion, polymerization, sonication and vibration are considered effective and economical. Microsponges are mostly used for topical use and now its applicability for oral administration is also justified. Thus, microsponges based drug delivery system has got a lot of potential and is one of the most evolving fields which needs exploration to understand its future in pharmaceuticals and biological sciences. This review deals with different fabrication techniques of microsponges along with their advantages and applications in present era and the future it beholds. Keywords: Microsponges, Delivery system, polymer, porous, topical
Publication date: 01/08/2024

https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8242.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.8.8242