ABSTRACT

Alcoholism in excess is a problem for heath worldwide. Since the liver is the main site of ethanol metabolism, heavy drinking causes the most tissue damage to it. Steatosis, hepatitis, and fibrosis/cirrhosis are the most recognizable liver lesions that are caused by chronic and heavy alcohol use. The first sign of heavy drinking is steatosis, which is characterized by the accumulation of fat in hepatocytes. Steatohepatitis, a more serious inflammatory form of liver disease, can develop from steatosis. This stage of liver illness can result in the growth of fibrosis, a condition in which an excessive amount of extracellular matrix proteins are deposited. Beginning with active pericellular fibrosis, the fibrotic response can develop to cirrhosis, which is characterized by excessive liver scarring, vascular changes, and ultimately liver failure. A number of disease modifiers worsen, impede, or stop the progression of alcoholic liver disease, resulting in around 35 percent of problem drinkers developing severe liver disease. Pharmacological or nutritional therapy for the treatment of people with alcoholic liver disease are still not FDA-approved. Abstinence from alcohol is a crucial component of therapy. The only treatment option for patients with advanced alcoholic liver damage is liver transplantation. Keywords: Alcoholic liver disease, alcoholic hepatitis, liver cirrhosis/fibrosis
Publication date: 01/08/2024

https://ijbpas.com/pdf/2024/August/MS_IJBPAS_2024_8215.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.8.8215