ABSTRACT

Daptomycin used as a treatment of Skin and soft tissue infections used in Diabetic foot ulcer. Aim of the study: Daptomycin was investigated for its wound healing effects in a diabetic foot ulcer rat model. Material and methods: To induce diabetic foot ulcers in Wistar rats, streptozotocin and Nicotinamide were utilized. Pentobarbitone sodium was used to anesthetize animals on day 7. On the dorsal surface of the foot, a rectangle was drawn, and the whole thickness of the skin (typical area 2–5 mm) was then excised. The ulcer area was calculated using ImageJ, a java-based programme. Result: The additional change in wound area from day 1 to day 7 for the daptomycin treatment groups in comparison to the disease control group was calculated using ulcer area measurement information. In a study on microbial colonization, the daptomycin-treated group had very few colonies grow. Conclusion: Following a seven-day course of daptomycin treatment, it is clear that the drug inhibits the development of significant consequences of diabetic foot ulcers. The study offers a rationale for daptomycin treatment in diabetic foot ulcers based on scientific evidence. Keywords: Diabetic foot Ulcer, Ulcer area measurement, Wound healing
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8207.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8207