ABSTRACT

Host toxicity and unfavourable side effects can frequently be reduced by synergistic interactions. It can also slow the development of drug related other problems. The current study's objective was to shed insight on the relationship between quercetin's antioxidant potential with that on the antioxidant potential of Stevia rebaudiana leaves. By using a 2,2-diphenyl-1-picrylhydrazyl inhibition assay; quercetin, extract and their blends (quercetin and stevia extract solutions) were evaluated for in vitro antioxidant screening. To build a Loewe additivity model, the drug's dose response relationship was determined. With the exception of the ratios 10:0.0120 and 10:0.0140, combinations have negative synergistism to variable degrees. The largest synergistic effects were seen at a ratio of extract: quercetin (10:0.0120). On the basis of the data, it is conceivable to use changes in the profiles of the extracts or in the ratios between different constituent groups to explain the broken relationship between combination indices and the activity of the extracts. Due to the extensive existence of polyphenols, the study may be applied to many plant components, notably those polyphenols. Keywords: Quercetin, Antioxidant, Stevia, Synergism, DPPH
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8203.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8203