ABSTRACT

The objective of this investigation was to formulate benzoyl peroxide (BPO) loaded liposomes. The liposomes were prepared using lecithin and cholesterol as the lipid forming agents using solvent evaporation method and sonication at 65 W power at 1 min pulses. Six formulations were prepared and characterized for particles size, drug entrapment and release study. The particle size of the liposome ranged from 2.22 to 8.01 ?m. The entrapment efficiency was found to be in the range of 2.143 to 53.77%. Sustained release of the encapsulated BPO was obtained, with less than 70% of the drug released in 24 h. The formulation was stable for a period of 12 weeks in accelerated conditions suggesting an improved stability of the drug. Keywords: Acne, benzoyl peroxide, liposome, stability, encapsulation, release
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8200.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8200