ABSTRACT

Urolithiasis is the condition where urinary calculi are formed or located anywhere in the urinary system, or the process of formation of stones in the kidney, bladder or ureters. The plants Moringa oleifera Lam (family: Moringceae) and Peltophorum pterocarpum DC (family: Fabaceae / Leguminosae) aqueous leaves extracts were investigated for its antiurolithiatic activity. Ethylene glycol (0.75% in water) induced resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Aqueous extracts of Moringa oleifera Lam and Peltophorum pterocarpum DC were given orally in (Groups III and IV) over a period of 15 to 28 days. The levels of urea, uric acid, creatinine, and protein in serum and urine were significantly (P<0.05) reduced by treatment with plant extract when compared to disease control (Group II). Histopathological examination showed that the treatment of plant extracts decreased the size of calcium oxalate deposits in different parts of the renal tubules and also prevent damage to the tubules and calyxes. The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility products of crystallizing salts such as calcium oxalate and calcium phosphate, whichcould contribute to the antiurolithiatic property of the extracts. Finally, the results suggested that the polyherbal formulation of aqueous leaves extracts of Moringa oleifera Lam and Peltophorum pterocarpum DC leaves have potent antiurolithiatic activity against ethylene glycol–induced calcium oxalate Urolithiasis in male albino rats. Keywords: Antiurolithiatic, Moringa oleifera Lam, Peltophorum pterocarpum DC, Ethylene glycol, calcium oxalate, kidney, cystone, Hyperoxaluria
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8186.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8186