ABSTRACT

Introduction: During the study and development of novel thrombolytic agents, it is an important consideration to evaluate the efficacy of thrombolytic drugs, which are commonly prescribed in medical settings and are the standard treatments for myocardial infarction and ischemic stroke. But currently available therapy has drawbacks such as bleeding, shortness of breath etc. In recent years there has been a tremendous increase in demand for herbal drugs because of its efficacy and better therapeutic results. Allium sativum is also considered to be therapeutically important in the traditional system of medicine. Method: To determine the Thrombolytic activity of Aqueous and Hydro-alcoholic extracts of Allium sativum Micro centrifuge tube method was performed. Results And Discussion: The Aqueous and Hydro alcoholic extracts of Allium sativum peel were subjected to phytochemical screening. The result indicated that peel extract shows the presence of carbohydrate, flavonoid, saponins and phenols. Aqueous garlic peel extract (200 ?g/ml, 400 ?g/ml, 800 ?g/ml) clot lysis, i.e. 13.66±0.01202, 16.33±0.00882, 19.33±0.00667 respectively, was obtained. When compared with the negative control (water) the mean clot lysis % of aqueous garlic peel extract, the difference was significant (P < 0.001 in all). When compared with the positive control (SK) the mean clot lysis % difference of all the two test i.e. aqueous, hydro alcoholic garlic peel extract was significant (P < 0.001 in all).After treatmentof clots with 100 ?l of Hydro alcoholic garlic peel extract (200 ?g/ml, 400 ?g/ml, 800 ?g/ml) clot lysis, i.e. 12.33±0.0833, 16.66±0.04387, 21±0.05774) respectively, was obtained. Conclusion: In conclusion, the present study, using In- vitro experiments established the aqueous and hydro alcoholic extracts have moderate Thrombolytic activity. Keywords: In – vitro, Thrombolytic activity, clot lysis
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8163.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8163