Introduction: The oral route is the most common route of administration of drugs because of the low
cost of therapy, ease of administration, patient compliance, and flexibility in formulation. Taking oral
medicine is extremely odious to some patients, such as paediatric and geriatric patients. Cefixime is one
of the most used antibacterial drugs, used in the treatment of the cough and cold. Difficulty in
swallowing (dysphagia) is common among paediatrics and geriatric patients. Accordingly, there is a
need for a solid form of medicine that is in a form easy to take and swallow, such as lollipops.
Objective: The main objective of the present research study is to provide a solid form of medicine that
is in a form that makes it pleasant to take and swallow by paediatrics, geriatric, and bedridden patients,
and avoid the dangers of being swallowed as do the other solid forms in those patients. However,
lollipop is designed to improve patient compliance, acceptability, transportation, etc. Materials and
Method In the present research study, an attempt has been made to prepare sugar-based cefixime
medicated lollipops for paediatrics, geriatrics, and bedridden patients to overcome the administration
problem. The cefixime medicated lollipops were prepared using dextrose and sucrose. All the
formulations prepared were subjected to various physicochemical parameters like hardness, friability,
weight variation, drug content, etc. Result: Drug-excipient compatibility study was carried out using
FTIR. All the formulations were subjected to various physicochemical evaluations like weight variation,
hardness, drug content, friability etc. The in-vitro dissolution study of F3 was carried out by two method
a) Paddle method b) flow through cell method. The in-vitro permeation study of F3 was found to be
68.5% at 20 min. Stability study was carried out as per ICH Guidelines (Q1A) at 25±2oC /60±5% RH
and 40±2oC /75±5% RH.
Conclusion: From present study it can be concluded that the combination of dextrose, sucrose and
HPMC K4M shows the best result of evaluation parameters and greater stability than other
combinations.
Keywords: Medicated lollipop, Cefixime, Pediatric, FTIR, ICH Guidelines
Publication date: 01/07/2024
https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8154.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.7.8154
