ABSTRACT

The present study carried out to investigate the antibacterial potential of lavangadi vati and its modified suspension dosage form, which is effectively giving in infectious respiratory conditions. The aim of the study is to determine its zone of inhibition and minimum inhibitory concentration against Klebsiella pneumonia, Staphylococcus aureus, Streptococcus mutans and standardisation by HPTLC fingerprinting. Antibacterial activity was performed by cup plate method and MIC method as a comparison between the both dosage form against different bacterial strains and results were compared with that of standard, Ciprofloxacin. In case of lavangadi vati, the growth of inhibition ranges from 10 to 20mm for all the sensitive bacteria whereas that of lavangadi vati suspension ranges from 8mm to 12mm.Lavangadi vati shown its minimum inhibitory concentration of 12.5 ?g/ml against K. pneumonia,25 ?g/ml against S. aureus,12.5 ?g/ml against S. mutans; whereas lavangadi vati suspension shown its minimum inhibitory concentration of 25 ?g/ml against K. pneumonia,50 ?g/ml against S aureus and 3.12 ?g/ml against S mutans. On HPTLC of the suspension, twelve spots were visualized at ultraviolet 254nm, nine spots at ultraviolet 366nm and 7 spots at visible light. Keywords: Lavangadi vati, minimum inhibitory concentration, Fourier transform infrared, anti- bacterial, suspension
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_8149.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.8149