ABSTRACT

Andrographis paniculata is used for its numerous beneficial effects primarily for liver disorders. Currently, its only one semi-solid dosage forms are available in the market. It has been found to have antiallergic and anti-inflammatory effects. Hence, a cream formulation of Andrographolide leaves extract was developed. HPLC and HPTLC method was successfully developed and validated for determination of Andrographolide from extract and cream formulation. HPLC was performed using a mixture of Potassium dihydrogen orthophosphate: and acetonitrile as a mobile phase while for HPTLC a mixture of Tolune, ethyl acetate, methanol, and formic acid was used. Both methods were found to be robust, accurate and precise. Keywords: Andrographis paniculata, cream formulation, HPLC, HPTLC
Publication date: 01/07/2024

https://ijbpas.com/pdf/2024/July/MS_IJBPAS_2024_7773.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.7.7773