ABSTRACT

The solubility of voriconazole a triazole antifungal drug in water is very low. The molecule is semi-polar (log D=1.8), making it difficult to solubilize with oils, surfactants, or water miscible co-solvents. It also breaks down by a retro-aldol reaction to compounds A and C. This instability is pronounced not only in aqueous media but also in solid state.Nanosponges are hypercross-linked cyclodextrin polymers that have recently been produced and are assembled into three-dimensional networks via nanostructure. Cyclodextrin undergoes a reaction with a cross-linking agent, like diphenyl carbonate or carbonyldiimidazole, to produce these polymers. Nanosponges based on cyclodextrin were able to complex a greater number of molecules than natural cyclodextrins. They limit the release of the weakly soluble actives, protect the labile groups, and improve solubility. The present study investigated whether cyclodextrin-based nanosponges may improve voriconazole chemical stability and water solubility. The results, indicate that the cyclodextrin nanosponges-based gel formulation of voriconazole offers great topical administration potential due to its delayed and consistent drug release, enhanced skin penetration, and good storage stability. Keywords: Voriconazole, nanosponges, cyclodextrin, solubility, stability
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_9181.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.9181