ABSTRACT

Aim: Present study aim is formulations and evaluations of bilayered Methyldopa tablets by natural polymers Method: Bilayered Methyldopa tablets were prepared by direct physical compression method using Guar Gum, Xanthan Gum (Natural), Sodium bicarbonates has a gas generating agent. The developed bilayered tablets are evaluated for physicochemical characters, buoyancy in vitro study, drug content, drug dissolution, Kinetic models, and drug stability studies. Results: the results are showing satisfactory and within the limits. The bilayered tablets consisting of CIR3 and CSR4 showing good floating property and drug release was found in a sustained manner for 12 hours and follows Higuchi kinetics. The optimised CIR3 and CSR4 bilayered tablet was more stable at various storage conditions. Conclusion: Methyldopa bilayered floating tablets were developed successfully by natural polymers and were stable for three months. Keywords: Methyl dopa, Gaur gum, Xanthan Gum, Buoyancy and bilayered tablets
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_9044.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2024/13.6.9044