ABSTRACT

Aim: to study the effects of curcumin on blood glucose, lipid profiles and Adiponectin activity in diabetic rats. Material and Methods: Diabetes mellitus was induced in male wistar rats, which were divided into seven groups and treated with 80mg, 100 mg curcumin/kg body weight and assessed the serum concentrations of blood glucose, insulin, lipid profiles (mg%) as triglycerides, total cholesterol, Low density lipoprotein (LDL)-Cholesterol, High density lipoprotein (HDL)-Cholesterol and Adiponectin. Results: this study results shows that diabetes mellitus increased the serum levels of glucose, total cholesterols, triglycerides, LDL-Cholesterol and decreased the adiponectin and HDL- Cholestrols, treatment with curcumin alone doses and combination with metformin can significantly decreased the serum levels of glucose, lipid profiles (p<0.001) and increased Insulin, Adiponectin treated groups (p < 0.001). Conclusion: In conclusions, the effects of curcumin on blood glucose, serum cholesterol, triglycerides and LDL-Cholesterol levels were decreased and increased the serum levels of Insulin, Adiponectin and HDL-C in curcumin treated groups. It can be suggested that the curcumin is useful for diabetes treatment. Keywords: Adiponectin, Curcumin, Lipid profiles, Blood glucose
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_9005.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.9005