ABSTRACT

Respiratory diseases are increasing day by day due to air pollution. Treatment of respiratory diseases using oral route of administration suffers disadvantage of first pass metabolism and requires larger dose of drugs. To overcome this problem targeted drug delivery is gaining much importance which reduces dose of a medicines and adverse effects. The pulmonary drug delivery system offers several merits over other drug delivery systems and therefore, this delivery route has been in prime focus for various applications like local and systemic therapeutics delivery. Pulmonary drug delivery can be used as an alternative to oral delivery. Pulmonary drug delivery is an important research area and is getting popularized for the treatment of pulmonary disease because it can directly deliver the drug to the lungs. Generally, most of the pharmaceuticals are not having good solubility in water but they are easily soluble in lipids, as in case of lungs both water soluble as well as lipid soluble drugs are absorbed by the tissues so this is not a restriction of pulmonary delivery. Carriers like micro particles, nanoparticles, liposomes can be used in lung targeting. Advances in device technology have led to the development of more efficient delivery systems capable of delivering larger doses and finer particles into the lung. The overall development of drug delivery system depends on its efficacy, quality, and safety and to achieve such attributes there is a need of reliable evaluation methods to test them. Herbal medicines are now a day preferred for the treatment of pulmonary diseases due to safety and efficacy. They are also having less side effects and wider acceptance. This review discusses different pulmonary drug delivery and herbal drugs via pulmonary drug delivery route for the treatment of various respiratory diseases. This review reflects about the human respiratory system, herbal dosage forms and devices used for delivery of drug. Keywords: Pulmonary drug delivery, herbal drugs, respiratory diseases
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8133.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8133