ABSTRACT

Sulphanilamide, known as a sulpha drug, possesses diverse pharmacological activities, making it a valuable chemotherapeutic agent for combating both bacteria gram-positive and gram- negative. This compound exhibits a broad spectrum of effects, including anti-hypoglycemic, diuretic, anti-hypertensive, antifungal, antibacterial, anti-inflammatory, and antiretroviral properties. Given the increasing prevalence of antibiotic resistance among existing drugs, there is a pressing need to develop novel derivatives of sulphanilamide to effectively combat bacterial and fungal infections. One key mechanism by which sulphanilamide derivatives combat microorganisms is through their competitive inhibition of folic acid synthesis enzymes. This action serves to hinder the growth of microorganisms. Consequently, in this comprehensive review, we highlight the synthesis of novel derivatives of sulphanilamide that exhibit the aforementioned pharmacological effects. By focusing on these newly synthesized derivatives, we aim to address the urgent need for effective therapeutic agents against bacteria and fungi in light of the growing resistance to conventional antibiotics. Keywords: Sulphonamide, Synthesis, Pharmacology, Antibacterial, heterocyclics
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8124.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8124