ABSTRACT

Ion exchange resins (IER) are acidic or basic functional groups containing insoluble polymers which have the ability to exchange counter-ions within the surrounding aqueous solutions. Based on the nature of the exchangeable ion of the resin as cation or anion, they are classified as cationic or anionic exchange resins. Ion exchange resins have considerable properties as the drug delivery vehicles which gained the attention from the pharmaceutical scientists. Physical properties such as degree of exchange capacity, cross-linkage, ionization, porosity and swelling, particle size and form, purity, toxicity and equilibrium rate influences the affinity of ion exchange resin. Ion exchange resins are widely used for various drug delivery and therapeutic applications. It is proven that Ion exchange resin are well suitable for drug delivery technologies such as the controlled drug release including various systems such as transdermal, nasal, topical, oral and taste masking. The drawback of sustained release or extended release such as dose dumping, toxicity can be avoided by the use of ion exchange resins have effective drug-retaining properties and the prevention of dose dumping and thus they have an important place in the development of the controlled or sustained release systems. The rate of drug dissolution is improved by converting drug to amorphous from by drug resin complexation. Drug delivery at the desired site of action made possible by the use of IER. This review deals with various types of ion exchange resin, their properties, chemistry & role of IER in controlled drug delivery systems along with therapeutic applications. Keywords: Anion exchange; Cation exchange; Resin; Controlled release; Resinates; Drug delivery
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8121.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8121