ENHANCING POTENTIALITY OF FLAVONOIDS BY PREPARING SEMI SYNTHETIC DERIVATIVES Authors: Usharani U* And Sreedevi A
ABSTRACT
In drug designing, molecular docking is used for understanding drug-receptor interaction. In
the present study Schiffs bases of chrysin were synthesized by using different amines.
Structures of the newly synthesized compounds were characterized by spectral studies.
Compounds were screened for their antibacterial activity and anthelmentic activity.
Compound 1A was found to be potent antibacterial against Staphylococcus aureus at 10?g/mL
compared to standard drug Ofloxacin and also 1a was found to be potential when compared to
standard drug Albendazole. Present study showed that by increasing water solubility of
flavonoids the biological activity may increases. All the compounds were subjected to
molecular docking studies for the inhibition of the enzyme DNA Gyrase (EC 5.99.1.3). The in
silico molecular docking study results showed that, all the synthesized compounds having
minimum binding energy and have good affinity toward the active pocket, thus, they may be
considered as good inhibitor of DNA Gyrase.
Keywords: Molecular docking, flavonoids, antibacterial activity, chrysin, Drug design Publication date: 01/06/2024 https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8115.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2024/13.6.8115
