ABSTRACT

Inflammation is a defense mechanism against any tissue injury. Along with various dosage forms, gels are used topically for inflammation. Herbal gels are preferred due to fewer side effects as compared to synthetic ones. Various non-aqueous herbal gels are available in the market, and the extraction from leaves is done using an organic solvent. This gel is made from an aqueous extract of Vitex negundo, family Lamiaceae. Extraction of leaves of Vitex negundo is done using the decoction technique. Phytoconstituents present in nirgundi leaves are alkaloids, phenolic compounds, carbohydrates, and saponins. Vitex negundo has anti- inflammatory action along with anti-ulcer, antioxidant, antinociceptive, and hepatoprotective. The gel is prepared using the base Carbopol 940. Four batches were prepared. Parameters for the evaluation of aqueous herbal gel are visual inspection (particulate matter), pH (pH meter), spreadability (spreadability apparatus), extrudability, viscosity (Brookfield viscometer), and diffusion study (Franz diffusion cell). Keywords: Vitex negundo, aqueous extract, diffusion, anti-inflammatory, herbal gel
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8109.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8109