ABSTRACT

Background: A characteristic of diabetes mellitus is usually high blood sugar levels. The absence of insulin results in an increase in blood sugar levels. Metformin is primarily used for the treatment of T2DM. Metformin by controlling blood glucose level decreases complications related to long term diabetes mellitus. Metformin blocks the absorption of Vitamin B12 from abdomen leading to its deficiency in body. The aim of this study is to assess the level of Vitamin B12 in patients with Type II diabetes mellitus treated with metformin. Materials & Methods: This Analytical cross sectional study was conducted in the Parul Sevashram, Hospital, Vadodara. We enrolled 100 type II diabetics on metformin therapy since past 1 year and aged 35-70 years and 100 healthy patients to analyze their blood glucose and serum vitamin B12 levels. Results: The Mean ±S. D of RBS of group-1 was 168.24 ±79.44 mg/dl, group-2 was 108.77 ±14.81 mg/dl. The Mean ± S.D of Vitamin B12 of group-1 was 246.36 ±118.50 pg/ml, group- 2 was 484.72 ±172.96 pg/ml. we found Strong negative correlation between Plasma blood glucose and Vitamin B12 in cases, having statistical sig P value = 0.0001 and r value was - 0.607. Conclusion: In the process of our study, we found a significant negative correlation between vitamin B12 insufficiency and using of metformin as a T2DM treatment. So, it is advisable that diabetes patients on metformin should undergo regular follow up for estimation of vitamins level to prevent further complications leading to better management. Keywords: Type II Diabetes mellitus, Metformin, Vitamin B12 deficiency, Oral Anti-diabetic drug
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8092.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8092