ABSTRACT

The identity of India is in its heritage and ethnically diversified endogamous populations characterized by unique custom, marriage system and occupation. It contributed a great genetic diversity or polymorphism in HLA system leading to linkage disequilibrium resulting in ethnically isolated sympatric populations. Hence, the genetic diversity of human populations can be traced by analyzing the highly polymorphic HLA antigenic profiles as markers. The present study aims at finding out the distribution of such HLA alleles and their haplotypes in the selected populations of Tamil Nadu state (South India). In this study, 222 healthy unrelated individuals from three endogamous groups such as Agamudayar (n = 74), Veerakudi Vellalar (n = 73), and Paraiyar (n = 75) inhabiting across southern region of Tamil Nadu were genotyped for HLA-A/-B, DRB1* and DQB1* alleles by the low-resolution-PCR-SSP method, and their Two-locus haplotypes were identified. Based on frequency distribution, alleles HLA- DRB1*15, DRB1*07, and DRB1*10 were identified as the predominant ones and are linked with the corresponding predominant DQ alleles to form predominant tow-locus HLA-DRB1*- DQB1* haplotypes. The most predominant two-locus haplotypes were DRB1*15-DQB1*06, DRB1*07-DQB1*02, and DRB1*10-DQB1*05. They revealed a positive linkage disequilibrium contributing unique ethnicity, novel, and evolutionarily conserved alleles and their haplotypes in all the three south Indian endogamous population groups studied. Keywords: HLA, HLA Antigens; Haplotype; Diversity; Linkage disequilibrium
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8079.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.6.8079