ABSTRACT

People of all ages and professions can be exposed to chemicals through the soil, water, air, food, and the impacts of chronic and acute poisonings have been well established for the common and noxious toxins. Malathion (MAL) is an organophosphate insecticide that disrupts the body’s antioxidant system; it is one of the earliest organophosphate insecticides extensively used as dust, emulsion, and vapor to control a wide variety of insect pests under different conditions. This study was designed to investigate the histological effect of O. oleaster leaves extracts on male mice hepatic tissues against malathion toxicity. Experimental mice were acclimatized for one week before experimental treatments. After the acclimatization period, the mice were divided into four groups. Mice of the first group were served as control. The experimental animals of the second group were exposed to malathion. Mice of the third group were treated with malathion at the same dose given to the second group and orally supplemented with O. oleaster leaves extracts. The animals of the fourth group were treated with O. oleaster leaves extracts. At the end of experimental period (8 weeks), mice of group 2 showed significant reduction of body weight and severe hematological and biochemical alterations including significant increases of ALT, AST, ALP and total bilirubin values. Severe histopathological alterations of liver tissues were observed in exposed MAL-intoxicated mice. Administration of the O. oleaster leaves extracts reduced the detected biochemical, histopathological modifications caused by MAL intoxication. Keywords: Malathion; Olea oleaster; Mice; Liver; Toxicity
Publication date: 01/06/2024

https://ijbpas.com/pdf/2024/June/MS_IJBPAS_2024_8063.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2024/13.6.8063