ABSTRACT

Yet Balanites aegyptiaca is most commonly preferred folk fore medicinal plant, there is no scientific finding still exists to express such diuretic potential. So present study was deal with investigation of the diuretic potential as well as lethal hazaradness for Balanites aegyptiaca (L.) Delile Fruit extract by using Wistar rat. Diuretic potential of alcoholic fruit extract investigated on albino rats within five different groups by using modified Lipschitz method in normal saline was used to hydrate test animal rats. Control group was treated with Normal saline (25mL/kg), 20mg/kg of furosemide was provided to the reference group, and various quantities of the ethanolic extract (i.e., 100, 250, and 500 mg/kg) were given to the test groups, respectively, through intra- peritoneal method. Statistical data was evaluated through Annova test with a threshold of significance of 0.05 was considered statistically significant. Test groups were shown positive diuretic activity with significant increase in a dose. While, urine’s pH unchanged. Ethanolic extract was interpreted for diuretic activity with the help diuretic index. At dose of 500 mg/kg, Lipschitz values express 46% diuretic activity in comparison to standard furosemide. There was nohazardous signs were observed in test animals during acute toxicity study yet at maximum dose up to 5000mg/kg. Keywords: Balanites aegyptiaca (L.) Delile Fruit, diuretic effect, modified Lipschitz method
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8652.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8652