ABSTRACT

Common gastrointestinal problems like nausea and vomiting can be brought on by a variety of emetic stimuli via the central and/or peripheral neural systems. When hazardous chemicals, medications, bacteria, viruses, or fungus enter the body through either the GI tract or injectable pathways, such as the cutaneous, pulmonary, or circulatory systems. Most typical pregnancy problem is indigestion and vomiting during gestation. The majority of the time, the symptoms appear in the first phase, but in a minimal number of instances, they can last the entire pregnancy as well as influence the woman's quality of life. Although the etiology of NVP is still not completely comprehended, it's also agreed that the disorder is complex and that a number of hereditary, endocrine, and viral variables may be at play. NVP treatment is currently aimed at reducing hazards to mother and fetus while focusing on alleviating symptoms. The most cutting-edge oral solid dose form is a film that dissolves in the mouth, thanks to its adaptability and user-friendliness. Oro- dispersible films are oral solid medication methods that, if inserted into the mouth without any water or chewing, instantly break down and dissolve. Such a dosage enables the medicament to skip the initial metabolic process, potentially increasing the bioavailability of the drug. This review presents insights on various commercially available mouth dissolving film products, formulation methodologies, and evaluation criteria. Keywords: Nausea; Vomiting; Pregnancy; Hyperemesis Gravidarum; oro- Dispersible film; Solvent casting
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8050.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8050