ABSTRACT

Urolithiasis is a process of stone formation in the urinary tract, affecting the kidneys, ureters, bladder or urethra. It is also termed as nephrolithiasis, urolithiasis or ureterolithiasis with a male- female ratio of 2:1. In the present study, we evaluated the in-vitro anti-urolithiatic activity of Physalis minima Linn. The shade dried and powdered plant material was subjected to cold maceration of coarsely powdered leaves of Physalis minima Linn., using n-hexane, ethyl acetate and ethanol. The extracts were then subjected to preliminary phytochemical screening, followed by in-vitro antioxidant and antiurolithiatic activity. The qualitative phytochemical results revealed the presence of flavonoids, phenol, sugar, lipids, steroids, tannins, saponins, fat, alkaloids and lignin. In-vitro antioxidant activity, determined by hydrogen peroxide assay, showed the ethanol extract with least IC50 value of 51.02?g/mL. Further the in-vitro anti-urolithiatic activity revealed that the ethanol extract of Physalis minima Linn., showed better antiurolithiatic activity than n-hexane and ethyl acetate extracts. Thus current study validates the antiurolithiatic potential of Physalis minima Linn., in the inhibition of stone formation and dissolution of stone crystals which might be due to the antioxidant property. Keywords: Physalis minima, hydrogen peroxide assay, urolithiasis
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8043.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8043