ABSTRACT

Background: Guggul is a natural gum resin used as traditional Indian medicine. Objective: The objective of the present study is to evaluate the nootropic activity of guggul oleo gum resin against scopolamine induced memory impairment in albino wistar rats. Methods: In this study 25 albino wistar rats were randomly selected and divided in to 5 groups. Each group consists of 5 animals - Group: 1(Control), Group: 2(negative control scopolamine 20mg/kg I.P), Group: 3(standard Donepazil 5mg/kg P.O), Group: 4&5 different versus of extract AECW (50mg&100mg/kg P.O). Memory impairment was induced with scopolamine at a single dose of 20mg/kg body weight i.p to the groups expect control group at 7th day estimation of behavioral studies was carried out by the Y-Maze, Labyrinth Maze, Elevated Plus Maze. Results: AECW treated groups shows transfer latency similar to the donepezil treated groups. Scopolamine treated groups show more transfer latency when compared with donepazil treated groups. Conclusion: The AECW has shown significant effect at a dose of 50mg/kg which is similar to standard donepazil 5mg/kg due to presence of phytochemical constituents like flavonoids, tannins,alkaloids, steroids. The investigation shows AECW has nootropic activity and at a standard level useful to mankind. Y-maze, Elevated Plus maze & Labyrinth maze are the standard methods used for evaluating memory. Keywords: Nootropic activity, scopolamine, donepazil, AECW, Y-maze, labyrinth maze, elevated plus maze, flavonoids, alkaloids, tannins, steroids
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8035.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8035