The formulation and evaluation of ibuprofen effervescent tablets have gained significant attention due
to their potential advantages over conventional tablet formulations. This study aimed to develop an
effective and stable formulation of ibuprofen effervescent tablets with improved drug dissolution and
patient compliance. Various formulations of ibuprofen effervescent tablets were prepared using different
excipients and evaluated for their physicochemical properties and in vitro drug release profile. The
tablets were formulated using a direct compression method, incorporating ibuprofen as the active
pharmaceutical ingredient along with effervescent agents, binders, disintegrants, and lubricants. the
formulation and evaluation of ibuprofen effervescent tablets proved successful in developing a stable
and effective formulation with improved drug release properties. These effervescent tablets have the
potential to provide faster and more efficient pain relief, making them a promising alternative to
conventional ibuprofen tablets. Further studies, including in vivo evaluations and clinical trials, are
warranted to validate their therapeutic efficacy and safety. Because they are simple to use and improve
compliance, fast-dissolving drug delivery systems have recently begun to acquire popularity and
acceptance as innovative drug delivery systems. Elderly folks often have trouble taking the tablet.
Ibuprofen prevents peripheral tissue from producing prostaglandins (PG). The purpose of this research
was to create effervescent tablets with enough mechanical integrity and to have them dissolve more
quickly in water. A compatibility examination of the drug's acids, bases, and other excipients was carried
out in the pre-formulation research, indicating that they are compatible with one another. Various acidsand bases were based in combination to make tablets. Additionally, tablets made with various binding
agents were tested for effervescences, hardness, friability, solution time, and pH. Tablets made with a
greater ratio of citric acid to sodium bicarbonate with pvp-K30 2% as the binder exhibit a quick solution
time, a higher pH, and excellent hardness.
Keywords: Ibuprofen, Effervescent tablets, Physicochemical properties, Drug dissolution,
Patient compliance, Excipients, Effervescent agents, Binders, Drug content uniformity
Publication date: 01/05/2024
https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8026.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.5.8026
