ABSTRACT

Liver fibrosis is a significant worldwide well-being matter which results towards numerous chronic liver injuries, including hepatic viral illnesses, biliary diseases, and chemically-made liver disorders. Extracellular matrix (ECM) overproduction & its substitution of liver parenchymal tissue along fibrotic tissue are two characteristics of liver fibrosis. The existing treatment is only can stop further damage & there is no approve therapy for same. The study aim is to give the polyherbal formulation that will act on different pathophysiological steps of liver fibrosis. Six group of albino wistar rats were being experimented in this case, group I to VI i.e. normal control, disease control, standard control & test group of three different doses of polyherbal formulation (Taraxacum Officinale root extract, Fermented Glycine max, Solanum nigrum leaves extract, Phyllanthus niruri extract) at high dose, intermediate dose & low dose based on acute oral toxicity. Conducting the study is seen that polyherbal formulation of high dose in compare to that of standard group (silymarin) is showing better efficacy by detection of various biochemical parameters also by detecting the histopathological parameters of every group according to plan of work and protocol for evaluation of formulation. As further it will come in future work can be done into cell line on molecular base to determine clinical significance. Keywords: Liver fibrosis, Tetracycline, polyherbal formulation, biochemical parameters, Silymarin
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8018.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8018